Transport between Kaliro and Buyende districts has been paralysed following the flooding of a section of the road at Lumbuye Swamp.
The same road connects Kaliro to Kamuli District.
On Sunday, a one-kilometre stretch of the road was flooded making it difficult for motorists and pedestrians to move.
Mr Jamal Nkobe, a resident, said the flooding started last month following heavy rains that washed away culverts at the road section.
Several parts of the country are experiencing torrential rainfall.
Some areas in Bundibugyo Bududa and Sironko districts experiencing landslides that have claimed dozens of lives and displaced hundreds of people.